S. Ory et P. Jurdic, Microtubules, cell compartments and Rho GTPases: a "menage a trois" for efficient migration, M S-MED SCI, 17(8-9), 2001, pp. 878-885
Dynamic cytoskeleton and membrane plasticity allow higher eucaryotic cells
to actively migrate. To move, cells need to correctly integrate both extra
and intracellular signals in order to completely reorganize their actin cyt
oskeleton and corresponding adhesion structures. It is well established tha
t RhoGTPases are pivotal regulators of actin organization making them. key
players in the Control of cell migration. Actin organisation between the le
ading and the rear edges of migrating cells is different, implying the exis
tence of polarized activation and antagonistic activities. of the RhoGTPase
s within the e cell. Recent data suggest that both microtubules and subcell
ular compartments influence the local distribution and polarized activity o
f RhoGTPases in migrating cells.