Neuropharmacological basis of stress moderation

The consequences of unfavourable environmental and endogenous changes induc ing stress in animals were discussed in this paper, and were based on the c lassic stress theory of Cannon and Selye. Dopamine and norepinerphrine, as neurotransmitters of motivation and subcor tical motor (earlier - extrapyramidal motor system) systems, play a very im portant role in stress development. Apart from the action of these hormones, the importance of endogenous opioi d peptides and glucocorticoides inducing adaptation as well as the contradi ctory influence of CCK2 were analysed. The anti-stress activity of neurolep tic and anxiolytic drugs, as well as antagonists of central CCK receptors i n animals confirm the importance of their influence.