Glucose disposal rates calculated from 60-to 90-minute isoglycemic hyperinsulinemic glucose clamp correlate with cardiovascular risk factors in borderline hypertensive young men

The hyperinsulinemic glucose clamp is generally performed for at least 120 minutes, due to assumptions of steady-state. We were interested in relation ships between glucose disposal rate (GDR) and cardiovascular risk factors, rather than a standard measure of insulin sensitivity per se. Therefore, we analyzed 120-minute clamps performed on borderline hypertensive, but other wise healthy young men (n = 19). GDR was calculated at different time point s and related to baseline cardiovascular risk factors and responses to a me ntal stress test (MST). The 60-, 90-, and 120-minute GDR correlated signifi cantly with serum high-density lipoprotein (HDL) cholesterol (r = .59, r = .50, and r = .53, respectively), heart rate (HR) during MST (r = -.65, r = -.64, and r = -.58, respectively) and plasma epinephrine (Epi) (r = -.55, r = -.58, and r = -.56, respectively) and norepinephrine (NE) (r = -.52, r = -.49, and r = -.48, respectively) 1 minute after announcement of the MST ( all P < .05). Although not statistically significant at all time points, si milar relationships were observed between GDR and resting HR, systolic bloo d pressure (BP) at rest and during mental stress, body mass index (BMI), se rum total cholesterol (Choi), serum triglycerides; (TG), and blood hemoglob in (HgB), with remarkable consistency from about 40 to 50 minutes onwards. HDL cholesterol and Epi remained independent in stepwise multiple regressio n analyses with the 60-, 90-, and 120-minute GDR as dependent variables (al l P < .05). We suggest that 60- to 90-minute glucose clamps may provide inf ormation about the relationship between insulin sensitivity and various car diovascular risk factors in borderline hypertensive young caucasian men. Co pyright (C) 2001 by WB. Saunders Company.