Porins from Salmonella enterica serovar typhimurium induce TNF-alpha, IL-6and IL-8 release by CD14-independent and CD11a/CD18-dependent mechanisms

Lipopolysaccharide (LPS) of Gram-negative bacteria and several surface comp onents of Gram-positive bacteria utilize CD14 and CD11a/18 as cellular rece ptors to induce expression and release of cytokines. of the surface compone nts of Gram-negative bacteria, porins exhibit a biological activity similar to that of LPS. The results in this paper show that the mechanism of stimu lation by porins of THP-1 cells enriched in CD14 receptor after treatment w ith 1,25-dihydroxyvitamin D-3 (vitamin D-3) is independent of this receptor , but is partially dependent on CD11a/18 integrins.