Pathophysiologic consequences of hydrocephalus

Hydrocephalus-induced damage is dependent on the rate and magnitude of vent ricular dilatation, the proximity to the ventricle, and the developmental s tage at which the disturbance occurs. It is mediated through a combination of mechanical, ischemic, and metabolic-toxic disturbances. Developmental pr ocesses, including myelin production, can be impaired. Periventricular axon s are the primary target, however. The potential for reversal of damage by shunting diminishes as the duration and severity of hydrocephalus increases . Ancillary pharmacologic means for preventing hydrocephalus-induced brain damage are worth pursuing.