Stimulus-secretion coupling and mitochondrial metabolism in steroid-secreting cells

Authors
Spat, A Pitter, JG Rohacs, T Szabadkai, G
Citation
A. Spat et al., Stimulus-secretion coupling and mitochondrial metabolism in steroid-secreting cells, NEWS PHYSL, 16, 2001, pp. 197-200
Citations number
15
Categorie Soggetti
Physiology
Journal title
NEWS IN PHYSIOLOGICAL SCIENCES
ISSN journal
08861714 → ACNP
Volume
16
Year of publication
2001
Pages
197 - 200
Database
ISI
SICI code
0886-1714(200110)16:<197:SCAMMI>2.0.ZU;2-8
Abstract
Ca2+ signal in high-Ca2+ perimitochondrial microdomains is amplified within the mitochondrial matrix and activates Ca2+-dependent dehydrogenases. In s teroid-secreting cells, small cytoplasmic Ca2+ signals may also augment mit ochondrial Ca2+ concentration. The ensuing formation of NADH and NADPH may have an essential role in supporting the increased steroid secretion.