J. Albright et al., Philadelphia panel evidence-based clinical practice guidelines on selectedrehabilitation interventions for neck pain, PHYS THER, 81(10), 2001, pp. 1701-1717
Introduction. A structured and rigorous methodology was developed for the f
ormulation of evidence-based clinical practice guidelines (EBCPGs), then wa
s used to develop EBCPGs for selected rehabilitation interventions for the
management of neck pain. Methods. Evidence from randomized controlled trial
s (RCTs) and observational studies was identified and synthesized using met
hods defined by the Cochrane Collaboration that minimize bias by using a sy
stematic approach to literature search, study selection, data extraction, a
nd data synthesis. Meta-analysis was conducted where possible. The strength
of evidence was graded as level I for RCTs or level II for nonrandomized,
studies. Developing Recommendations. An expert panel was formed by inviting
stakeholder professional organizations to nominate a representative. This
panel developed a set of criteria for grading the strength of both the evid
ence and the recommendation. The panel decided that evidence of clinically
important benefit (defined as 15 % greater relative to a control based on p
anel expertise and empiric results) in patient-important outcomes was requi
red for a recommendation. Statistical significance was also required but wa
s insufficient alone. Patient-important outcomes were decided by consensus
as being pain, function, patient global assessment, quality of life, and re
turn to work, providing that these outcomes were assessed with a scale for
which measurement reliability and validity have been established. Validatin
g the Recommendations. A feedback survey questionnaire was sent to 324 prac
titioners from 6 professional organizations. The response rate was 51%. Res
ults. For neck pain, therapeutic exercises were the only intervention with
clinically important benefit relative to a control (grade A for pain and fu
nction, grade B for patient global assessment). There was good agreement wi
th this recommendation from practitioners (93%). For several interventions
and indications (eg, thermotherapy, therapeutic ultrasound, massage, electr
ical stimulation), there was a lack of evidence regarding efficacy. Conclus
ions. This methodology of developing EBCPGs provides a structured approach
to assessing the literature and developing guidelines that incorporates cli
nicians' feedback and is widely acceptable to practicing clinicians. Furthe
r well-designed RCTs are warranted regarding the use of several interventio
ns for patients with neck pain where evidence was insufficient to make reco
mmendations.