Pro-pro amide bond configuration and the immunosuppressive activity of cyclolinopeptide A

Authors
Krajewski, K Lisowski, M Wieczorek, Z Siemion, IZ
Citation
K. Krajewski et al., Pro-pro amide bond configuration and the immunosuppressive activity of cyclolinopeptide A, POL J CHEM, 75(10), 2001, pp. 1441-1448
Citations number
10
Categorie Soggetti
Chemistry
Journal title
POLISH JOURNAL OF CHEMISTRY
ISSN journal
01375083 → ACNP
Volume
75
Issue
10
Year of publication
2001
Pages
1441 - 1448
Database
ISI
SICI code
0137-5083(200110)75:10<1441:PABCAT>2.0.ZU;2-1
Abstract
The comparison of conformational preferences of cyclolinopeptide A (CLA) an alogues containing the twisted cis-amide bond mimetics, based on CD, molecu lar modeling, and their immunosuppressive activity was performed. The resul ts suggest that there exists a twisted cis-amide bond between two proline r esidues in the biologically active conformation of CLA.