Recognition of pseudolesions of the liver at computed tomography (CT) is im
portant because of their close resemblance to primary liver cancers or meta
stases. Two types of pseudolesion in the noncirrhotic liver include that du
e to transient extrinsic compression, typically caused by ribs or the diaph
ragm, and that due to a "third inflow" of blood from other than the usual h
epatic arterial and portal venous sources: the cholecystic, parabiliary, or
epigastric-paraumbilical venous system. Although the location of both type
s of pseudolesion are characteristic, their appearances at CT during arteri
al portography and CT during selective angiography vary from nonenhanced lo
w-attenuation areas to well-enhanced high-attenuation areas, depending on t
he amount and timing of the inflow and presence or absence of focal metabol
ic alteration of the hepatocytes. Radiologists need to understand the under
lying mechanism of these pseudolesions to better recognize the wide range o
f their appearances at CT.