Intravenous multivitamin formulation for use in pediatric total parenteralnutrition

Background: No intravenous multivitamin formulation is available at the Chi lean market that fulfills the requirements of pediatric patients on total p arenteral nutrition. Therefore, adult formulations must be used. Aim: To pr epare a parenteral aqueous multivitamin solution, to be used in pediatric p atients. Material and methods: The solution was prepared, mixing vitamins a ccording to their stability and compatibility in a horizontal laminar flow hood. The quality control for this formulation at times zero and 30 days co nsisted of an Organoleptic analysis, microbiologic and pyrogen controls and vitamin quantification. In addition, tbe effect of vitamin solution incorp oration on the stability of total Parenteral nutrition,formulae was evaluat ed. The approximated production cost was calculated. Results: The ampoules did not show changes on the organoleptic characteristics. No bacterial cont amination or pyrogens were detected. Total parenteral nutrition solutions w ere not modified after tbe incorporation of the vitamins. be vitamin soluti on tvas stable for one month at 4 degreesC Conclusions: The manufacture Of this formulation results in significant savings, because it bas a low manuf acturing cost and fulfills pediatric requirements.