Influence of electrostatic interactions and hydrogen bonding on the activity of cyclodextrin-based superoxide dismutase models

Authors
Fragoso, A Cao, R Diaz, A Sanchez, I Sanchez, L
Citation
A. Fragoso et al., Influence of electrostatic interactions and hydrogen bonding on the activity of cyclodextrin-based superoxide dismutase models, SUPRAMOL CH, 13(5), 2001, pp. 619-625
Citations number
21
Categorie Soggetti
Chemistry
Journal title
SUPRAMOLECULAR CHEMISTRY
ISSN journal
10610278 → ACNP
Volume
13
Issue
5
Year of publication
2001
Pages
619 - 625
Database
ISI
SICI code
1061-0278(2001)13:5<619:IOEIAH>2.0.ZU;2-U
Abstract
The influence of electrostatic interactions and hydrogen bonding between th e substrate and the active site in superoxide dismutase (SOD) models based on Cu(II) complexes of cyclodextrin dithiocarbamates is studied. Polar and positively charged groups present in the structure of the complexes were fo und to increase its activity in 35-70%. Our studies reveal the importance o f these two features in enhancing the activity of SOD model complexes.