Radioiodine therapy is currently the treatment of choice for metastasizing
differentiated thyroid cancer (DTC); however, skeletal metastases are resis
tant to this form of therapy. The surgical removal of distant metastases fr
om DTC offers the best chance for prolonged survival and improved quality o
f life. Furthermore, the surgical removal of a resectable skeletal metastas
is can be a valuable complement to radioiodine therapy. This report describ
es two cases of sternal metastases from thyroid carcinoma that were managed
successfully by surgery involving partial excision of the sternum followed
by reconstruction of the chest wall with Marlex mesh. Both patients recove
red uneventfully. Sternal resection with Marlex mesh reconstruction of the
chest wall defect proved a simple and effective method for managing sternal
metastasis. Thus, the surgical resection of distant bony metastases in pat
ients with DTC is recommended as it can be curative, provide symptomatic pa
lliation, or allow for more effective radioiodine treatment.