Synthesis of a PNA-peptide conjugate by chemical ligation

Authors
de Koning, MC Filippov, DV Meeuwenoord, N Overhand, M van der Marel, GA van Boom, JH
Citation
Mc. De Koning et al., Synthesis of a PNA-peptide conjugate by chemical ligation, SYNLETT, (10), 2001, pp. 1516-1518
Citations number
33
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
10
Year of publication
2001
Pages
1516 - 1518
Database
ISI
SICI code
0936-5214(200110):10<1516:SOAPCB>2.0.ZU;2-X
Abstract
A convergent synthetic route to the construction of a PNA-N-to-C-peptide co njugate (PKKKRKVGC-ttgcatt) by regioselective condensation of a thioester p eptide and a cysteine-PNA adduct under denaturating conditions is described .