Synthesis of 6-hydroxybenzothiazole-2-carboxylic acid

Authors
Lowik, DWPM Tisi, LC Murray, JAH Lowe, CR
Citation
Dwpm. Lowik et al., Synthesis of 6-hydroxybenzothiazole-2-carboxylic acid, SYNTHESIS-S, (12), 2001, pp. 1780-1783
Citations number
18
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
SYNTHESIS-STUTTGART
ISSN journal
00397881 → ACNP
Issue
12
Year of publication
2001
Pages
1780 - 1783
Database
ISI
SICI code
0039-7881(200109):12<1780:SO6A>2.0.ZU;2-T
Abstract
The synthesis of 6-hydroxybenzothiazole-2-carboxylic acid (1) is presented. The benzothiazole ring was obtained by ring contraction of a remarkably st able 2-alkoxy-7-hydroxy-2H-benzo[1,4]thiazine intermediate that could be is olated. 6-Hydroxybenzothiazole-2-carboxylic acid was found to slowly decarb oxylate in solution at ambient temperature.