Synthesis of triketide delta-lactones

Authors
Kim, SJ Kang, HY Sherman, DH
Citation
Sj. Kim et al., Synthesis of triketide delta-lactones, SYNTHESIS-S, (12), 2001, pp. 1790-1793
Citations number
21
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
SYNTHESIS-STUTTGART
ISSN journal
00397881 → ACNP
Issue
12
Year of publication
2001
Pages
1790 - 1793
Database
ISI
SICI code
0039-7881(200109):12<1790:SOTD>2.0.ZU;2-V
Abstract
An efficient synthetic route was developed to prepare substituted delta -la ctones 1 and 2 in enantiopure forms which are potentially useful for biosyn thetic studies with genetically engineered modular polyketide synthase (PKS ). The key step to prepare the target epimeric lactones involves the samari um(II) iodide-mediated Reformatsky reaction.