Effect of molecular sieves in the liquid-phase synthesis of nucleotides via the phosphoramidite method

Authors
Hayakawa, Y Hirata, A Sugimoto, J Kawai, R Sakakura, A Kataoka, M
Citation
Y. Hayakawa et al., Effect of molecular sieves in the liquid-phase synthesis of nucleotides via the phosphoramidite method, TETRAHEDRON, 57(42), 2001, pp. 8823-8826
Citations number
30
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
57
Issue
42
Year of publication
2001
Pages
8823 - 8826
Database
ISI
SICI code
0040-4020(20011015)57:42<8823:EOMSIT>2.0.ZU;2-J
Abstract
It is demonstrated that the reaction of a nucleoside phosphoramidite and a nucleoside aided by a suitable promoter in the presence of molecular sieves 3A or 4A in a liquid phase is efficiently performed by the use of stoichio metric amounts of the reactants to give the desired coupling product in an excellent yield. (C) 2001 Elsevier Science Ltd. All rights reserved.