Efficient synthesis of optically active beta-hydroxy p-tolylsulfones with very high enantiomeric excess via CBS-oxazaborolidine-catalyzed borane reduction

Authors
Cho, BT Kim, DJ
Citation
Bt. Cho et Dj. Kim, Efficient synthesis of optically active beta-hydroxy p-tolylsulfones with very high enantiomeric excess via CBS-oxazaborolidine-catalyzed borane reduction, TETRAHEDR-A, 12(14), 2001, pp. 2043-2047
Citations number
28
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
12
Issue
14
Year of publication
2001
Pages
2043 - 2047
Database
ISI
SICI code
0957-4166(20010814)12:14<2043:ESOOAB>2.0.ZU;2-P
Abstract
A simple, efficient synthesis of optically active beta -hydroxy p-tolylsulf ones with > 99% e.e. by employing CBS oxazaboronlidene-catalyzed asymmetric borane reduction of beta -keto p-tolylsulfones using N-ethyl-N-iso-propyla niline-borane complex as the borane carrier has been established. (C) 2001 Elsevier Science Ltd. All rights reserved.