Six stereoisomers of a new camphor-derived 1,7,7-trimethyl-2'-iso-propylspi
ro[bicyclo[2.2.1]heptane-2,4'-(1,3-dioxane)] odorant were prepared. Their d
esign with the help of an amber olfactophore model and structure-odour rela
tionship are reported. The (IR,2S,4R,2'S) isomer has by far the strongest a
nd the most characteristic amber-like odour. (C) 2001 Elsevier Science Ltd.
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