A new module arrangement for plasmapheresis

On-line plasmapheresis using microporous membranes for filtration normally requires two external circulations (double treatment) before the detoxified plasma can be returned to the patient. The duomodule, a new filter arrange ment developed by our group, integrates both steps in one equipment module using only one external circuit. Separations of aqueous polyethylene glycol (PEG) solutions as well as human plasma were carried out using the duomodu le arrangement. The results revealed a considerable decrease of higher mole cular substances in the feed solutions and a significant increase of these components in the permeate solution accumulated in the external compartment of the module. In conclusion, the duomodule arrangement seems to be an use ful tool for the therapeutic apheresis. (C) 2001 Elsevier Science Ltd. All rights reserved.