Type B1 thymoma in multiple endocrine neoplasia type 1 (MEN-1) syndrome

Aims and background: Multiple endocrine neoplasia (MEN) syndromes include a group of disorders characterized by the neoplastic transformation of two o r more endocrine tissues. In type 1 syndrome (MEN-1), pituitary, parathyroi d and pancreatic islet tumors are most frequently represented. Thymic neopl asms are also rarely associated, and thymectomy during subtotal or total pa rathyroidectomy should always be considered. Study design: The authors describe a rare case of a 22-year-old male who pr esented a type B1 thymoma without myasthenia gravis associated to hyperpara thyroidism, corticoadrenal adenoma and three neuroendocrine pancreatic lesi ons (somatostatinoma, glucagonoma and insulinoma).