Hk. Altes et al., Effector cytotoxic T lymphocyte numbers induced by vaccination should exceed levels in chronic infection for protection from HIV, VACCINE, 20(1-2), 2001, pp. 3-6
Recent technological advances have revolutionised our capacity to induce cy
totoxic T lymphocyte (CTL) responses with a variety of vaccine formulations
and delivery systems. However, the conditions required for a CTL-inducing
vaccine to provide protection from infection or disease are poorly understo
od, and the results of challenge experiments have not been consistent. Here
we use a mathematical model to examine the requirements necessary for succ
essful vaccination against human immunodeficiency virus (HIV) through cellu
lar immunity. We describe the interaction between cytotoxic T cells and inf
ected lymphocytes, capturing the essence of a persistent infection of immun
e cells. We conclude that to protect from infection. the cellular immune re
sponse should be boosted to levels exceeding those in chronic infection. Th
is requires either that effector CTL exceed this threshold before infection
, or that a memory CTL population is established that can yield this level
of effector CTL very quickly upon infection. (C) 2001 Elsevier Science Ltd.
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