The WHO Vaccine Trial Registry prospectively registers clinical vaccine stu
dies supported by WHO. Through December 1999, the registry includes 103 stu
dies from 43 countries, with nearly 80% in developing countries. The regist
ry documents an expanding research capacity, with an average of 3.9 new stu
dies per year during 1987-1993, rising to 10.7 per year during 1994-2000. T
he studies concern a broad spectrum of infectious organisms, including: Clo
stridium tetani (tetanus), dengue virus, enterotoxigenic Escherichia coli (
ETEC), Haemophilus influenzae type b (Hib), hepatitis B virus, measles viru
s, Mycobacterium tuberculosis, Neisseria meningitidis (meningococcus), poli
ovirus, respiratory syncytial virus (RSV), rotavirus, Salmonella typhi, Shi
gella, Streptococcus pneumoniae (pneumococcus), and Vibrio cholerae. (C) 20
01 WHO. Published by Elsevier Science Ltd. All rights reserved.