Generalized pustulous psoriasis: A novel extraintestinal manifestation of Crohn's disease?

A 66-year-old female patient suffering for 10 years from Crohn's disease fi rstly presented with a parallel outbreak of generalized pustulous psoriasis and Crohn's disease. A second synchronous exacerbation of both disorders o ccurred after discontinuation of treatment with prednisolone, methotrexate, and mesalazine. As to their pathogenetic concepts, both disease entities r eveal similar immunologic alterations, i.e. comparable patterns of cytokine s, chemokines, and inflammatory cells (T cells and neutrophils). Generalize d pustulous psoriasis, therefore, might develop as hitherto undescribed, mo re rare extraintestinal manifestation of Crohn's disease.