Matrix metalloproteinases: Promoters of tumor invasion and metastasis - A review with focus on gastrointestinal tumors

Authors
Roeb, E Matern, S
Citation
E. Roeb et S. Matern, Matrix metalloproteinases: Promoters of tumor invasion and metastasis - A review with focus on gastrointestinal tumors, Z GASTROENT, 39(9), 2001, pp. 807-813
Citations number
68
Categorie Soggetti
Gastroenerology and Hepatology
Journal title
ZEITSCHRIFT FUR GASTROENTEROLOGIE
ISSN journal
00442771 → ACNP
Volume
39
Issue
9
Year of publication
2001
Pages
807 - 813
Database
ISI
SICI code
0044-2771(200109)39:9<807:MMPOTI>2.0.ZU;2-5
Abstract
Degradation of basement membrane and extracellular matrix is crucial for in vasion and metastasis of tumor cells. Proteolysis occurs via matrix metallo proteinases and is tightly controlled by specific endogenous proteinase inh ibitors. This review will summarize the current view on the role of matrix metallopr oteinases in tumor growth, invasion and metastasis and focus on the importa nce of matrix metalloproteinases in gastrointestinal cancer.