Electronystagmographic findings in patients with cerebral degenerative disease

Cerebral degenerative diseases produce a variety of abnormal neuro-otologic al findings on electronystagmography (ENG). To assess their diagnostic valu e and determine which manifestations are helpful in making a diagnosis, ENG findings from 72 cases of confirmed cerebral degenerative disease were ana lyzed. We observed a high incidence of saccadic pursuit and upward ocular d ysmetria, which is likely to be useful in diagnosing cerebral degenerative disease. In contrast, moderate incidences of horizontal ocular dysmetria, g aze-evoked and rebound nystagmus, vertical positioning nystagmus and impair ed visual suppression appeared to reflect the degree of dysfunction, while optokinetic nystagmus appeared to reflect both the presence of disease and its severity. Cases of spinocerebellar ataxia 6 and spinocerebellar ataxia 3 tended to produce horizontal and vertical gaze-evoked nystagmus, whereas progressive supranuclear palsy produced a higher incidence of upward gaze-e voked nystagmus, and positioning nystagmus at the sagittal plane appeared f requently in cases of non-hereditary spinocerebellar degeneration.