Major changes will impact the way national immunization programmes and serv
ices are planned and implemented over the next decade and beyond. This pape
r presents the most significant health policy contexts, the relevant featur
es of health systems development and new prospects for service delivery. It
outlines ways of transforming a dedicated disease control programme, polio
eradication, for a broader health agenda. Progress anticipated in research
for new vaccines and technologies is described. Reaching the new targets b
eing established will require strong partnerships and the recent creation o
f the Global Alliance for Vaccines and Immunizations is an important step i
n this direction. (C) 2001 Elsevier Science B.V. All rights reserved.