Synthesis of some new thio uracil derivatives with expected biological activity

Simple synthesis of 5-substituted heterocycle thiouracil was acheived start ing with the conveniently available 2-thiouracil via chlorosulphonation, ad dition and condensation reactions of (I) double under bar followed by cycli zation of the obtained polyfunctionally substituted materials which were fo und to be dependent on the nature of the variable heteroatom.