P300, disinhibited personality, and early-onset alcohol problems

Background: Recent research suggests that a reduced P300 amplitude of the e vent-related potential is associated with a vulnerability to alcoholism. Th is study tested the hypothesis that reductions in the P300 amplitude would be associated with specific dimensions of disinhibited personality (social deviance proneness and impulsivity) and that these personality traits would mediate the association between P300 and alcohol problems in a young adult sample that varied widely in disinhibitory traits. Methods: Alcohol problems, personality (impulsivity, social deviance, harm avoidance, and excitement seeking), and event-related potentials were measu red in a sample of 190 subjects (87 men, 103 women) with a mean age of 20.7 +/-1.9 years. Results: Social deviance, impulsivity, and alcohol problems were associated with reductions in the P300, but only in male subjects. A structural model suggested that social deviance, impulsivity, and alcohol problems were all strongly related to P300 amplitude at Fz. Further analyses indicated that for male subjects, social deviance mediated the association between P300 at Fz and alcohol problems as well as the association between impulsivity and alcohol problems. Conclusions: This study suggests that reduced P300s are strong ly associate d with a general tendency toward antisocial, defiant, and impulsive traits, which might, in turn, increase the risk for alcohol abuse, The lack of an association between reduced P300s and personality or alcohol problems in wo men was unexpected and deserves further study.