Urinary excretion of vasoactive factors are correlated to sodium excretion

Background: The relationship between urinary vasoactive factors and sodium excretion has not been adequately addressed in humans. Procedure: Excretion rates of sodium, nitrates/nitrites (NOx), cGMP, and en dothelin-1 (ET-1) were measured before and after ingestion of a mixed elect rolyte solution (8 oz Gatorade) while undergoing a routine cardiovascular e valuation in a sample of 51 normotensive young adults. Results: Significant correlations were detected for changes in excretion be tween all four variables, r ranged from 0.50 to 0.86 (P < .001). Correlatio ns were higher in African Americans than white Americans. Conclusions: The association of renal ET-1 and NO activity with sodium excr etion supports the hypothesis that these factors play a role in the physiol ogic response to acute changes in sodium intake, particularly in African Am ericans. Am J Hypertens 2001;14:1003-1006 (C) 2001 American Journal of Hype rtension, Ltd.