Total triterpenic fraction of Centella asiatica in chronic venous insufficiency and in high-perfusion microangiopathy

Total triterpenic fraction of Centella asiatica (TTFCA) is effective in imp roving venous wall alterations in chronic venous hypertension and in protec ting the venous endothellum. TTFCA is active on connective tissue modulatio n, improves the synthesis of collagen and other tissue proteins by modulati ng the action of fibroblasts in the vein wall, and stimulates collagen remo deling in and around the venous wall. This is due to the modulating action of TTFCA on fibroblasts as shown by experiments on the growth of human embr yonal fibroblasts. TTFCA has a moderate in-vitro and in-vivo stimulating ef fect on collagen synthesis and, at higher dosages, an inhibition on the syn thesis of collagen and acid mucopolysaccharides. Studies have indicated the role of TTFCA on the synthesis of specific venous wall elements by cell cu ltures of human embryonal fibroblasts, The tissue-stimulating action is sho wn by the increased collagen production independent from the stimulation of cell proliferation (this differentiates the action of TTFCA from cell grow th factors). TTFCA is active on the microcirculation in venous and diabetic microangiopathy. Signs and symptoms of venous hypertension and edema are i mproved by treatment. The remodeling on collagen synthesis could be one of the possible mechanisms of actions of TTFCA in the remodeling of echolucent (soft; therefore, with risk of thrombosis and embolization) plaques at the carotid and femoral bifurcation. This compound is safe and well tolerated. In conclusion, several actions of TTFCA in vascular diseases makes the use of this compound very interesting in venous and arterial problems.