Fungal phospholipase activity and susceptibility to lipid preparations of amphotericin B

Authors
Gottfredsson, M Jessup, CJ Cox, GM Perfect, JR Ghannoum, MA
Citation
M. Gottfredsson et al., Fungal phospholipase activity and susceptibility to lipid preparations of amphotericin B, ANTIM AG CH, 45(11), 2001, pp. 3231-3233
Citations number
5
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
11
Year of publication
2001
Pages
3231 - 3233
Database
ISI
SICI code
0066-4804(200111)45:11<3231:FPAAST>2.0.ZU;2-F
Abstract
It has been postulated that phospholipases of fungal origin can affect in v itro susceptibility testing of amphotericin B lipid complex (ABLC). We used specific phospholipase-deficient mutants of Candida albicans and Cryptococ cus neoformans in susceptibility testing and demonstrated that extracellula r fungal phospholipase activity does not influence the in vitro susceptibil ities of these two fungi to ABLC.