Congeners of SMAP29 kill ovine pathogens and induce ultrastructural damagein bacterial cells

Authors
Kalfa, VC Jia, HP Kunkle, RA McCray, PB Tack, BF Brogden, KA
Citation
Vc. Kalfa et al., Congeners of SMAP29 kill ovine pathogens and induce ultrastructural damagein bacterial cells, ANTIM AG CH, 45(11), 2001, pp. 3256-3261
Citations number
16
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
11
Year of publication
2001
Pages
3256 - 3261
Database
ISI
SICI code
0066-4804(200111)45:11<3256:COSKOP>2.0.ZU;2-F
Abstract
SMAP29, an ovine cathelicidin, was systematically altered to create a famil y of 23 related peptides for MIC and minimum bactericidal concentration det erminations. SMAP28, SMAP29, and a derivative of SMAP29 called ovispirin we re all antimicrobial. However, many congeners of SMAP29 and ovispirin were not as active as the parent molecules. With immunoelectron microscopy, SMAP 29 was seen on membranes and within the cytoplasm of Pseudomonas aeruginosa PAO1.