Cloning and biochemical characterization of FOX-5, an AmpC-type plasmid-encoded beta-lactamase from a New York City Klebsiella pneumoniae clinical isolate

Authors
Queenan, AM Jenkins, S Bush, K
Citation
Am. Queenan et al., Cloning and biochemical characterization of FOX-5, an AmpC-type plasmid-encoded beta-lactamase from a New York City Klebsiella pneumoniae clinical isolate, ANTIM AG CH, 45(11), 2001, pp. 3189-3194
Citations number
24
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
11
Year of publication
2001
Pages
3189 - 3194
Database
ISI
SICI code
0066-4804(200111)45:11<3189:CABCOF>2.0.ZU;2-6
Abstract
Klebsiella pneumoniae 5064, isolated in New York, carried plasmid-mediated resistance to multiple beta -lactams and was unresponsive to clavulanic aci d. The beta -lactamase gene responsible for cephalosporin resistance encode d FOX-5, with 96 to 97% amino acid identities to other members of the FOX f amily of beta -lactamases. The bla(FOX-5) coding region was located next to a transposase gene from the Aeromonas salmonicida insertion element ISAS2.