Citation
Lf. Discotto et al., Staphylococcus aureus mutants selected by BMS-284756, ANTIM AG CH, 45(11), 2001, pp. 3273-3275
Citations number
7
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804
→ ACNP
Volume
45
Issue
11
Year of publication
2001
Pages
3273 - 3275
Database
ISI
SICI code
0066-4804(200111)45:11<3273:SAMSBB>2.0.ZU;2-1
Abstract
BMS-284756, a novel des-fluoro(6)-quinolone, was used to select for in vitr
o mutants of Staphylococcus aureus ISP794. Step mutants were obtained, and
the quinolone resistance-determining regions of four target genes, gyrA, gy
rB, grlA, and grlB, were sequenced. The data suggest that DNA gyrase is the
primary target for BMS-284756 in S. aureus.