Synergistic activities of gatifloxacin in combination with other antimicrobial agents against Pseudomonas aeruginosa and related species

Authors
Gradelski, E Valera, L Bonner, D Fung-Tomc, J
Citation
E. Gradelski et al., Synergistic activities of gatifloxacin in combination with other antimicrobial agents against Pseudomonas aeruginosa and related species, ANTIM AG CH, 45(11), 2001, pp. 3220-3222
Citations number
17
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
11
Year of publication
2001
Pages
3220 - 3222
Database
ISI
SICI code
0066-4804(200111)45:11<3220:SAOGIC>2.0.ZU;2-6
Abstract
Drug combinations have been used to treat serious infections caused by Pseu domonas, Burkholderia, Stenotrophomonas, and Acinetobacter. In this study, the combined drug effects of gatifloxacin (GAT) and nonquinolones were dete rmined by time-kill analysis at clinically achievable drug concentrations. Synergy (greater than or equal to2 log(10)-enhanced killing at 24 h) was ob served with GAT plus amikacin or a beta -lactam against 50 to 75% of strain s, including strains nonsusceptible to one or both drugs.