Activities of a new fluoroketolide, HMR 3787, and its (des)-fluor derivative RU 64399 compared to those of telithromycin, erythromycin A, azithromycin, clarithromycin, and clindamycin against macrolide-susceptible or -resistant Streptococcus pneumoniae and S-pyogenes

Authors
Nagai, K Davies, TA Ednie, LM Bryskier, A Palavecino, E Jacobs, MR Appelbaum, PC
Citation
K. Nagai et al., Activities of a new fluoroketolide, HMR 3787, and its (des)-fluor derivative RU 64399 compared to those of telithromycin, erythromycin A, azithromycin, clarithromycin, and clindamycin against macrolide-susceptible or -resistant Streptococcus pneumoniae and S-pyogenes, ANTIM AG CH, 45(11), 2001, pp. 3242-3245
Citations number
27
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
11
Year of publication
2001
Pages
3242 - 3245
Database
ISI
SICI code
0066-4804(200111)45:11<3242:AOANFH>2.0.ZU;2-T
Abstract
Activities of HMR 3787 and RU 64399 were compared to those of three macroli des, telithromycin, and clindamycin against 175 Streptococcus pneumoniae is olates and 121 Streptococcus pyogenes isolates. HMR3787 and telithromycin w ere the most active compounds tested against pneumococci. Telithromycin and RU 64399 were equally active against macrolide-susceptible (MICs, 0.008 to 0.06 mug/ml) and -resistant S. pyogenes isolates, but HMR 3787 had lower M ICs for ermB strains.