Efficacies of clarithromycin regimens against Mycobacterium xenopi in mice

Authors
Lounis, N Truffot-Pernot, C Bentoucha, A Robert, J Ji, BH Grosset, J
Citation
N. Lounis et al., Efficacies of clarithromycin regimens against Mycobacterium xenopi in mice, ANTIM AG CH, 45(11), 2001, pp. 3229-3230
Citations number
10
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
11
Year of publication
2001
Pages
3229 - 3230
Database
ISI
SICI code
0066-4804(200111)45:11<3229:EOCRAM>2.0.ZU;2-0
Abstract
Mice were infected intravenously with 3.5 X 10(7) CFU of Mycobacterium xeno pi and treated with various clarithromycin-containing regimens or left untr eated for 4 weeks. All nine of the clarithromycin-containing regimens reduc ed the CFU counts to the levels below the pretreatment values, indicating t hat these regimens had a bactericidal effect on M. xenopi in mice. The rifa mpin-isoniazid-ethambutol regimen was significantly less bactericidal than clarithromycin alone or clarithromycin-containing combined regimens.