E. Ribera et al., Rifampin reduces concentrations of trimethoprim and sulfamethoxazole in serum in human immunodeficiency virus-infected patients, ANTIM AG CH, 45(11), 2001, pp. 3238-3241
To determine whether rifampin reduces concentrations of trimethoprim (TMP)
and sulfamethoxazole (SMX) in serum of human immunodeficiency virus (HIV)-i
nfected persons, levels of these agents were determined by high-performance
liquid chromatography before and after more than 12 days of standard antit
uberculosis treatment for 10 patients who had been taking one double-streng
th tablet of co-trimoxazole once daily for more than 1 month. Statistically
significant, 47 and 23% decreases in TMP and SMX mean areas under the conc
entration-time curve from 0 to 24 h (AUC(0-24)), respectively, were observe
d after administration of rifampin. N-Acetyl-SMX profiles without and with
rifampin were similar. The steady-state AUC(0-24) metabolite/parent drug ra
tio increased by 32% with rifampin administration. Our study shows that rif
ampin reduces profiles of TMP and SMX in serum of HIV-infected patients.