NGF ANTIBODIES IMPAIR LONG-TERM DEPRESSION AT THE MOSSY FIBER CA3 SYNAPSE IN THE DEVELOPING HIPPOCAMPUS

Authors
RUBERTI F BERRETTA N CATTANEO A CHERUBINI E
Citation
F. Ruberti et al., NGF ANTIBODIES IMPAIR LONG-TERM DEPRESSION AT THE MOSSY FIBER CA3 SYNAPSE IN THE DEVELOPING HIPPOCAMPUS, Developmental brain research, 101(1-2), 1997, pp. 295-297
Citations number
19
Categorie Soggetti
Neurosciences
Journal title
Developmental brain research → ACNP
ISSN journal
01653806
Volume
101
Issue
1-2
Year of publication
1997
Pages
295 - 297
Database
ISI
SICI code
0165-3806(1997)101:1-2<295:NAILDA>2.0.ZU;2-Z
Abstract
Nerve growth factor (NGF) and other neurotrophins are proteins involve d in neuronal survival and differentiation. Much experimental evidence is now drawing attention into a role of neurotrophins in activity-dep endent synaptic plasticity processes. We now show that slices from rat s chronically deprived of NGF, by intraventricular injection of alpha D11 hybridoma cells, which produce monoclonal antibodies against NGF, display a reduced probability of induction of long-term depression at the messy fibre-CAS synapse. (C) 1997 Elsevier Science B.V.