Status of selenium and antioxidant enzymes of goitrous children is lower than healthy controls and nongoitrous children with high iodine deficiency

In order to investigate the relations of iodine deficiency and/or goiter wi th selenium (Se) and antioxidant enzyme (AOE) status, we determined the rel evant parameters of goitrous high school children living in an endemic goit er area of Turkey. Subjects were selected by a simple random sampling techn ique after screening the whole population of the high schools of two towns by neck palpation. The results of the goitrous group (n = 48, aged 15-18 yr ) were compared with those of nongoitrous control children (n = 49) from th e same populations, and with an outside control group (n = 24) from a lower -goiter-prevalence area. The overall prevalence of goiter was 39.6% in the high school population of the area. Activities of erythrocyte AOE (glutathi on peroxidase, catalase, and superoxide dismutase) and concentrations of pl asma and erythrocyte Se and urinary iodine were found to be significantly l ower in goitrous children than both in-region and out-region of the control groups. When the whole study group was reclassified according to the sever ity of iodine deficiency, it was found that the AOE and Se status of those control children without goiter but with high iodine deficiency was signifi cantly higher than goitrous children, although they did not differ from non deficient control group. This might be the result of the possibility that g oitrous children are exposed of oxidative stress, which may introduce alter ations to the antioxidant defense system and/or the antioxidant status is r elatively lower in goitrous children than those children who are highly iod ine-deficient but did not develop goiter. The results of this study seem to support the view that the risk of goiter development may be higher in high ly iodine-deficient children with lower enzymatic antioxidant and Se status .