Young male albino mice of Swiss strain were exposed to nickel by oral route
of 20 mg nickel sulfate/kg body weight for 5 d/wk for 6 mo. A decrease in
normal (testosterone-dependent) proteinuria was shown, and morphological ex
amination of the seminal vesicles revealed a lower weight and smaller size
as well as a histological indication of lower secretory activity of the epi
thelium compared to controls. The findings are consistent with a theory imp
lying a decreased testosterone activity in nickel-treated animals.