Studies on 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase using chorismate mutase inhibitors

Authors
Birck, MR Husain, A Sheflyan, GY Ganem, B Woodard, RW
Citation
Mr. Birck et al., Studies on 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase using chorismate mutase inhibitors, BIOORG MED, 11(21), 2001, pp. 2795-2798
Citations number
24
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
21
Year of publication
2001
Pages
2795 - 2798
Database
ISI
SICI code
0960-894X(20011105)11:21<2795:SO3A8S>2.0.ZU;2-J
Abstract
The proposed cyclic mechanism of 3-deoxy-D-manno-octulosonic acid 8-phospha te synthase and the mechanism of chorismate mutase share certain structural and electronic similarities. In this report, we examine several inhibitors of chorismate mutase for their efficacy against KDO 8-P synthase. (C) 2001 Elsevier Science Ltd. All rights reserved.