Amino acid phosphoramidate nucleosides: Potential ADEPT/GDEPT substrates

Authors
McIntee, EJ Wagner, CR
Citation
Ej. Mcintee et Cr. Wagner, Amino acid phosphoramidate nucleosides: Potential ADEPT/GDEPT substrates, BIOORG MED, 11(21), 2001, pp. 2803-2805
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
21
Year of publication
2001
Pages
2803 - 2805
Database
ISI
SICI code
0960-894X(20011105)11:21<2803:AAPNPA>2.0.ZU;2-9
Abstract
A series of aromatic, serum-stable, water soluble and nontoxic amino acid p hosphoramidate monoesters of 5-fluoro-2'-deoxyuridine (FUdR) and 1-beta -ar abinofuranosylcytosine (Ara-C) was shown to inhibit the cellular growth of the human leukemia cell line CCRF-CEM in the presence of human prostatic ac id phosphatase (hPAP). (C) 2001 Elsevier Science Ltd. All rights reserved.