This report describes nine unrelated cats with acute idiopathic polyne
uropathy. All cats presented with acutely developing tetraparesis or t
etraparalysis and loss of spinal reflexes. Seven cats recovered comple
tely within 4 to 6 weeks, without any medication. Two years after comp
lete recovery, none of these cats had had a relapse. In the acute stag
e, two cats were euthanized because of respiratory complications. Post
mortem examination was performed on one of these cats and revealed gen
eralized peripheral motor polyneuropathy. The clinical signs in these
cats were identical to those of the Guillain-Barre syndrome in humans.