Design and synthesis of a novel class of histone deacetylase inhibitors

Authors
Lavoie, R Bouchain, G Frechette, S Woo, SH Abou Khalil, E Leit, S Fournel, M Yan, PT Trachy-Bourget, MC Beaulieu, C Li, ZM Besterman, J Delorme, D
Citation
R. Lavoie et al., Design and synthesis of a novel class of histone deacetylase inhibitors, BIOORG MED, 11(21), 2001, pp. 2847-2850
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
21
Year of publication
2001
Pages
2847 - 2850
Database
ISI
SICI code
0960-894X(20011105)11:21<2847:DASOAN>2.0.ZU;2-Y
Abstract
Histone deacetylase inhibitors (HDACs) have emerged as a novel class of ant iproliferative agents. Utilizing structure-based design, the synthesis of a series of sulfonamide hydroxamic acids is described. Further optimization of this series by substitution of the terminal aromatic ring yielded HDAC i nhibitors with good in vitro and in vivo activities. (C) 2001 Elsevier Scie nce Ltd. All rights reserved.