Potent, low molecular weight thrombin receptor antagonists

Authors
Chackalamannil, S Doller, D Eagen, K Czarniecki, M Ahn, HS Foster, CJ Boykow, G
Citation
S. Chackalamannil et al., Potent, low molecular weight thrombin receptor antagonists, BIOORG MED, 11(21), 2001, pp. 2851-2853
Citations number
27
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
21
Year of publication
2001
Pages
2851 - 2853
Database
ISI
SICI code
0960-894X(20011105)11:21<2851:PLMWTR>2.0.ZU;2-H
Abstract
Several benzimidazole derivatives have been identified as potent thrombin r eceptor (PAR-1) antagonists as represented by compound 1h, which showed an IC50 of 33 nM. (C) 2001 Elsevier Science Ltd. All rights reserved.