2-(anilinomethyl)imidazolines as alpha(1)-adrenoceptor agonists: The identification of alpha(1A) subtype selective 2 '-carboxylic acid esters and amides

Authors
Bishop, MJ Berman, J Bigham, EC Garrison, DT Gobel, MJ Hodson, SJ Irving, PE Liacos, JA Minick, DJ Navas, F Saussy, DL Speake, JD
Citation
Mj. Bishop et al., 2-(anilinomethyl)imidazolines as alpha(1)-adrenoceptor agonists: The identification of alpha(1A) subtype selective 2 '-carboxylic acid esters and amides, BIOORG MED, 11(21), 2001, pp. 2871-2874
Citations number
20
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
21
Year of publication
2001
Pages
2871 - 2874
Database
ISI
SICI code
0960-894X(20011105)11:21<2871:2AAATI>2.0.ZU;2-O
Abstract
2-(Anilinomethyl)imidazolines with 2'-esters or 2'-amides are potent agonis ts of the cloned human alpha (1)-adrenoceptors in vitro. The size and shape of the ortho substituent can have significant effects on the potency. effi cacy, and subtype selectivity of these 2-(anilinomethyl)imidazolines. alpha (1A)-subtype selective agonists have been identified. (C) 2001 Elsevier Sc ience Ltd. All rights reserved.