Malignant transformation of multiple dermal cylindromas

Cylindromas are benign tumours arising as small, solitary, slow-growing nod ules on the head and neck. Multiple cylindromas may form a 'turban tumour' in the autosomal dominant Brooke-Spiegler syndrome. We report two unusual c ases of multiple cylindromas with transformation into cylindrocarcinomas. T he first patient, a 63-year-old white woman, developed a cylindrocarcinoma on pre-existing multiple cylindromas on her right shoulder. Eight months af ter resection she developed a lymph node metastasis in the right axilla. Th e second patient, a 68-year-old white woman, presented with multiple cylind romas of the scalp. One of these transformed into a cylindrocarcinoma, infi ltrating the dura mater, with local recurrence 2 years after incomplete res ection and postoperative radiation.