Blastic mantle cell lymphoma associated with Burkitt-type translocation and hypodiploidy

Authors
Vaishampayan, UN Mohamed, AN Dugan, MC Bloom, RE Palutke, M
Citation
Un. Vaishampayan et al., Blastic mantle cell lymphoma associated with Burkitt-type translocation and hypodiploidy, BR J HAEM, 115(1), 2001, pp. 66-68
Citations number
10
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
BRITISH JOURNAL OF HAEMATOLOGY
ISSN journal
00071048 → ACNP
Volume
115
Issue
1
Year of publication
2001
Pages
66 - 68
Database
ISI
SICI code
0007-1048(200110)115:1<66:BMCLAW>2.0.ZU;2-3
Abstract
Two elderly men with stage IV mantle cell lymphoma (MCL) rapidly developed a leukaemic phase with unusually high blast counts that proved fatal. One l ymph node biopsy showed diffuse MCL, the other blastic morphology. In addit ion to t(11;14), there were t(8;14) and t(1;19) in case 1 and dup(8)(q24q13 ) in case 2. Fluorescence in situ hybridization revealed genomic fusion of IgH/MYC genes in case 1 and an extra copy of C-MYC gene in case 2. The geno mic alteration of C-MYC oncogene is probably implicated in the blastic tran sformation and aggressive behaviour of the disease.