Abnormal dicentric chromosome with co-amplification of sequences from chromosomes 11 and 19: a novel rearrangement in a patient with myelodysplastic syndrome transforming to acute myeloid leukemia

Authors
Smith, A St Heaps, L Sharma, P Jarvis, A Forsyth, C
Citation
A. Smith et al., Abnormal dicentric chromosome with co-amplification of sequences from chromosomes 11 and 19: a novel rearrangement in a patient with myelodysplastic syndrome transforming to acute myeloid leukemia, CANC GENET, 130(1), 2001, pp. 29-32
Citations number
15
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER GENETICS AND CYTOGENETICS
ISSN journal
01654608 → ACNP
Volume
130
Issue
1
Year of publication
2001
Pages
29 - 32
Database
ISI
SICI code
0165-4608(20011001)130:1<29:ADCWCO>2.0.ZU;2-X
Abstract
A 66-year-old man with a myelodysplastic syndrome transforming to acute mye loid leukemia showed a complex abnormal karyotype on bone marrow aspirate. An unbalanced dicentric translocation with a very long der(11) long arm-dic (11; 19)(q25;p13.4)-was present. Fluorescence in situ hybridization studies utilised paints for chromosomes 11 and 19 a, well as the locus specific pr obe MLL, localised to 11q23. The abnormal chromosome 11q contained 6 copies of intact MLL and 6 copies of chromosome 19 (unidentified) sequences. To o ur knowledge, gene co-amplification of chromosomes 11 and 19 sequences has not been reported before. (C) 2001 Elsevier Science Inc. All rights reserve d.